Brighton will monitor the fitness of Neal Maupay, who was forced off against Liverpool with a hamstring problem.
Tariq Lamptey is back from a ban but Adam Lallana is ruled out after injuring his groin at Anfield, while this game may come too soon for Davy Propper and Alexis Mac Allister.
Southampton will assess Danny Ings, who returned to full training on Thursday after a month out with a knee injury.
Nathan Redmond may also come back into contention following a hamstring issue.
LAWRO'S PREDICTION
Southampton have got some good unsung players including James Ward-Prowse, who scored those two cracking goals against Aston Villa and grabbed another in the defeat by Manchester United last week.