Arsenal midfielder Granit Xhaka begins a three-match suspension as a result of his red card against Burnley.
Hector Bellerin is also banned for accumulating five bookings but Nicolas Pepe is available after completing a suspension.
David Luiz is unlikely to make his comeback from a head injury for this match, while Thomas Partey's thigh injury is expected to keep him out.
Southampton manager Ralph Hasenhüttl has a fully-fit squad at his disposal.
LAWRO'S PREDICTION
Arsenal did not give up against Burnley, even with 10 men, but they are clearly lacking belief at the moment.