Even though South Carolina and Mississippi State (formerly Mississippi A&M) both began playing football in the mid-1890s and were co-members in the old Southern Intercollegiate Athletic Association and the Southern Conference - which is as old-school, Southern-fried as you can get - strangely the Gamecocks and Bulldogs never met on the gridiron until USC joined the SEC in 1992.
State, of course, was one of the original thirteen SEC members who broke off from the SoCon in 1932; Carolina cleaved to the Southern until joining the ACC in 1952 as a charter member, and ultimately going the independent route from 1971-1991.