No. 16 LSU scored the game's first eight runs on the way to a 9-4 victory over visiting South Alabama on Wednesday night in Baton Rouge.
With the loss, the Jaguars fall to 9-8 this season. USA opens Sun Belt Conference play on Friday at home against Louisiana-Monroe.
On Wednesday, LSU (12-6) scored two runs in the first, one in the fourth, four in the fifth and one in the sixth to lead 8-0. Hunter Fedducia and Zach Watson both had two-run singles for the Tigers, who also scored on RBI singles by Hal Hughes and Bryce Jordan and added two more on bases-loaded walks.