Mark Hughes' first act as Southampton manager was to guide the Saints to their first FA Cup semi final since 2003, as Wigan's incredible run finally came to an end.
Nick Powell missed out on a starting place for Wigan due to a hamstring complaint, so Gary Roberts played on his 34th birthday. Hughes made two changes to Mauricio Pellegrino's final lineup, with Sofiane Boufal and Manolo Gabbiadini replacing James Ward-Prowse and Nathan Redmond.
The League One side began in enterprising fashion and nearly took the lead when Nathan Byrne shot through a crowd of players, and the ball inched agonisingly past the post with Chey Dunkley a toe-end away from making decisive contact.