Son Heung-Min will lead the Tottenham Hotspur attack at Manchester United in place of the injured Harry Kane.
Tottenham talisman Kane is missing with a hamstring strain so Son will play as a false nine.
Moussa Sissoko, Ben Davies and Eric Dier return to the team, while Kieran Trippier and Davinson Sanchez drop to the bench in the other changes from the 4-1 win over Liverpool.
United boss Mourinho identified Sanchez as Ajax's weak link ahead of the Europa League final in May and this is the first big match he has missed. Dier could play in midfield or as part of a back three.