Quique Setien is concerned for Ousmane Dembele though is unsure if Barcelona will have to make signings to replace the injured winger.
The France international had been working his way back from a hamstring issue in the same leg which had kept him out since November.
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News of Dembele's injury was somewhat overshadowed by Lionel Messi's public criticism of Barca director Eric Abidal on Tuesday, though the 22-year-old's continued absence leaves Setien short of numbers up top, with Luis Suarez also out.