The pair's shootout at San Siro could go a long way towards deciding the winner of this year's prize, while Atletico Madrid has a shot at history - and revenge over rival Real.
For the second time in three seasons, Real Madrid will meet Atletico Madrid in the final of the Champions League. Two years on from a dramatic encounter in Lisbon, the pair will lock horns again, this time in Milan on Saturday.
Given their longstanding rivalry, we look set for a scintillating showdown at San Siro that throws up the possibility of a plethora of talking points.