Eusebio Di Francesco makes a total of five changes from the side that beat Barcelona 4-2 last time out. Federico Fazio and Aleksandar Kolarov slide into defence, replacing Konstantinos Manolas and Davide Santon respectively. In midfield, Bryan Cristante and Javier Pastore will operate either side of Daniele De Rossi, as opposed to the partnership of Kevin Strootman and Lorenzo Pellegrini who find themselves starting the match from the bench. In attack, Di Francesco chooses Diego Perotti over Justin Kluivert.
Real Madrid change their shape from the 4-2-3-1 they used against Juventus to a 4-3-3 to mirror their opponents.