Arsenal's three-win streak came to a halt at Goodison Park on Sunday as Everton defeated the Gunners 1-0 thanks to a first-half strike from late replacement Phil Jagielka.
Jagielka came into Marco Silva's XI and captained the Toffees after Michael Keane was declared sick, poking home from short range after 10 minutes in what was the game's only goal.
The Gunners stay fourth despite their defeat but remain level on points with Chelsea and just two points ahead of Manchester United in sixth.
Pierre-Emerick Aubameyang is Arsenal's top scorer this season on 17 goals, but the Gabon international was again on the bench and failed to find the back of the net after he came on at half-time.