Premier League leaders Liverpool host Brighton & Hove Albion on Saturday hoping to increase their eight-point cushion at the top of the table.
England's top outfits return from their European commitments in Week 14, when Chelsea host West Ham United and defending champions Manchester City are on the road to Newcastle United.
Jose Mourinho will make his home Premier League debut as Tottenham Hotspur manager when they host Bournemouth, while Unai Emery's Arsenal will be tested by a trip to face Norwich City on Sunday.
Second-place Leicester City will hope they can beat Everton at home to keep touch with the front-runners, while Manchester United host Aston Villa.