Emuidzhi Oghiabekhva netted four goals while Nadege Cisse and Letago Madiba scored once for Minsk in Wednesday's 12-0 Champions League thrashing of Bettembourg.
Nigeria's Oghiabekhva, who was the only striker to score against Barcelona before the Champions League final last season, opened the scoring five minutes into the match in Ukraine.
Three minutes later, Cote d'Ivoire's Cisse doubled the lead for the Belarusian side before Anastasia Shuppo made it 3-0 in the 16th minute.
Oghiabekhva got her second of the game and Minsk's fourth in the 26th minute before Tamila Khimich netted the fifth on the brink of half time.