Three teams in the East have the chance to clinch a place in the playoffs, while teams in the West fight for position.
| Friday, Sept. 18 | |||||
| 7:00 | Sporting Kansas City | - | FC Dallas | UniMas | |
| Saturday, Sept. 19 | |||||
| 2:00 | Toronto FC | - | Colorado Rapids | MLS Live | |
| 7:00 | New York City FC | - | San Jose Earthquakes | MLS Live | |
| 7:00 | D. | ||||