Mexico can take a decisive lead in Group B of the CONCACAF Nations League if they beat Panama at the Estadio Azteca on Tuesday, their first home game of the inaugural tournament.
El Tri put five past Bermuda on Friday to move level on points with their competition, but Gerardo Martino's side can establish daylight for the first time with victory in Mexico City.
Panama haven't won any of their last seven meetings with this opponent and last defeated Mexico in July 2013; however, Mexico have also failed to score more than once in 90 minutes in their last six encounters.