Mamelodi Sundowns will square off with Highlands Park in a Premier Soccer League (PSL) match at Loftus Versfeld Stadium on Wednesday.
The Tshwane giants are coming off an impressive 5-0 win over AmaZulu FC in the Telkom Knockout Cup Round of 16 match on Sunday.
Pitso Mosimane's side will now be looking to maintain its unbeaten start to the current league campaign having defeated Black Leopards 2-1 in their last game in the competition.
Meanwhile, Highlands Park sneaked into this year's Telkom Knockout Cup quarter-finals after defeating Leopards 6-5 on penalties following a 0-0 draw on Sunday.