Since Santiago Solari's appointment as Real Madrid manager, Isco has struggled for game time leading to interest from some of the Premier League's biggest clubs.
Isco has made 14 appearances thus far this season but most of his minutes came in the truncated reign of Julen Lopetegui. Since Solari has been in charge, the Spanish playmaker has yet to start a game for Real Madrid.
Isco's situation has interested the likes of Chelsea, Manchester United, Tottenham and Manchester City, as reported by the Mirror.
Should Real Madrid make their move for Chelsea's Eden Hazard in January, there is a chance that Isco will be used as a makeweight in the deal.