Sampdoria were undone by two familiar faces as Inter went top of Serie A with a 3-2 win despite a late fightback.
Mauro Icardi scored twice and Milan Skriniar was also on target as they came back to haunt former club Sampdoria and send Inter to the top of Serie A, for 24 hours at least, with a 3-2 win on Tuesday.
Having claimed a thrilling 3-2 derby win over AC Milan and then held Napoli to a 0-0 draw in their last two games, Luciano Spalletti's men continued their unbeaten start to the season with a dominant display at San Siro.