The forward appeared to be injured in a clash with Bulgaria defender Ivan Turitsov during the first half at Stade de France.
France striker Karim Benzema limped out of Tuesday's friendly against Bulgaria in a worrying sight for Les Bleus.
The Real Madrid star has been recalled to the national team after a six-year absence and is poised to play a starring role for his country at Euro 2020.
But that could now be in doubt after the 33-year-old picked up a knock in the first half against Bulgaria.