FC Schalke grabbed a hard-fought 1-0 win at Krasnodar on Thursday, while Southampton suffered their first loss in the 2016-17 UEFA Europa League against Inter Milan.
Osmanlispor held Villarreal to a 2-2 draw, and Fiorentina cruised to a 3-1 win over Slovan Liberec.
Manchester United and AS Roma will play later on Thursday.
Here's a look at Thursday's result:
Europa League Results
| Steaua Bucuresti | 1-1 | FC Zurich |
| Osmanlispor | 2-2 | Villarreal |
| Hapoel Beer Sheva | 0-1 | Sparta Prague |
| Inter | 1-0 | Southampton |
| Slovan Liberec | 1-3 | Fiorentina |
| Qarabag FK | 2-0 | PAOK Thessaloniki FC |
| FC Krasnodar | 0-1 | Schalke 04 |
| Salzburg | 0-1 | Nice |
| Shakhtar Donetsk | 5-0 | Gent |
| Konyaspor | 1-1 | Braga |
| Celta Vigo | 2-2 | Ajax |
| Standard Liege | 2-2 | Panathinaikos |
| Manchester United | tbd. |