Arsenal collapsed at Rennes in the UEFA Europa League on Thursday, losing their first-leg match 3-1 in the last 16.
The Gunners took the lead, but the Ligue 1 side fought back to earn a significant advantage as the visitors were reduced to 10 men in the first half.
Slavia Prague collected a 2-2 draw on the road, stunning La Liga outfit Sevilla.
However, there was better news for Spanish sides as Villarreal won 3-1 at Zenit St. Petersburg.
Eintracht Frankfurt and Inter Milan played out a goalless draw during their first leg in Germany.