Manchester United face Stoke City in the early kick off at Britannia Stadium on Boxing Day in round 18 of the Premier League.
Louis van Gaal is under huge pressure with no wins in the last six games, and another poor result on Saturday could see his side losing further ground in the Premier League title race.
Guus Hiddink takes charge of his first game as interim manager at Chelsea when the champions – 15th in the league and 11 points off the top four – face Watford at Stamford Bridge.
Premier League leaders Leicester City visit Anfield to face Liverpool, who are without a win in their last four games.