Nicolas Albarracin impressed as Wanderers moved into Copa Libertadores' knockout stages, while Boca Juniors stayed perfect.
Wanderers joined Boca Juniors in advancing from Group Five to the Copa Libertadores' round of 16 on Thursday, while Internacional claimed the top spot in Group Four.
Boca completed a perfect group-stage campaign with a 2-0 victory over Palestino, while Wanderers triumphed 3-0 away to Zamora to secure the second position in Group Five.
Wanderers hit the front in the 34th minute in Venezuela when Matias Santos slid in to turn Joaquin Verges' cross past Zamora goalkeeper Edward Ibarbo.
Nicolas Albarracin doubled the visitors' lead in impressive fashion just after the hour-mark, controlling the ball on the edge of the area before driving it into the bottom corner, while the midfielder teed up Gaston Rodriguez in the 88th minute to complete the win.