Sofiane Boufal hobbled off the pitch in Southampton's 2-1 home loss to Burnley on Saturday.
Ralph Hasenhuttl was forced to make an early change in the 39th minute after the 29-year-old, who was making his 17th Premier League appearance of the season, suffered a knock.
Boufal was subsequently replaced by Mali's Moussa Djenepo but Saints bowed to defeat as they recorded their 13th loss in the 2019-20 league campaign.
39: #SaintsFC forced into an early change, as @sosoboufal19 picks up an injury.
On comes @MoussaDjenepo2 !