A win apiece between them means defeat for either Bolivia or Colombia in La Paz could leave its World Cup hopes in tatters.
Bolivia and Colombia will hope to spark a turnaround in fortunes in their respective World Cup qualifying campaigns when they meet in La Paz on Thursday.
Julio Cesar Baldivieso's hosts and their Jose Pekerman's visitors have one win apiece so far to lie eighth and seventh respectively in the gruelling CONMEBOL grind for a place at Russia 2018.
Colombia are without a victory since beating Peru 2-0 on matchday one, with a 20th-minute goal from Lucas Biglia enough for Argentina to leave Barranquilla with the points last time out in November.