Western Kentucky is 5-2 against the spread in its last seven battles with Power 5 conference teams, while LSU is just 5-7 ATS in its last dozen meetings with non-Power outfits. The Tigers step out of SEC play to host the Hilltoppers Saturday night down at Death Valley.
Point spread: Tigers opened as 17-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 40.2-24.2 Tigers
Why the Western Kentucky Hilltoppers can cover the spread
Western Kentucky opened this season with a victory over one SEC team (Vanderbilt), and now gets a shot at another, of the big-game variety.