The Louisville Cardinals were a great road bet last season, going 5-1 against the spread and covering their last four road contests in a row. The Cardinals begin this season away from home when they take on Auburn in an interesting matchup at the neutral Georgia Dome on Saturday afternoon in Atlanta.
Point Spread: The Tigers opened as 10.5-point favorites, according to sportsbooks monitored by Odds Shark (see line updates and matchup report)
College football pick, via Odds Shark's computer: 21.0-20.1 Tigers
Why the Louisville Cardinals can cover the spread
Louisville only returns nine starters from a team that went 9-4 last season but also adds several quality transfers for its second season under head coach Bobby Petrino.