LSU is 4-1 both straight up and against the spread in its last five meetings with Florida, but the Gators are making some big noise this season under new head coach Jim McElwain, especially on defense. However, that defense might have its hands full with Heisman Trophy-candidate running back Leonard Fournette when the teams hook up down in Death Valley on Saturday night.
Point spread: Tigers opened as 6.5-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report)
College football pick, via Odds Shark computer: 23.