On FanDuel Sportsbook, the Los Angeles Rams are 2.5-point road favorites over the Seattle Seahawks, and the total is listed at 54.5 points. That makes the implied score 28.50-26.00 in favor of LA.
For those unfamiliar, single-game slates feature five flex spots with identical scoring to the main slate. However, kickers are included in these contests, and there is an "MVP" roster slot. The MVP receives 1.5-times his total fantasy points, making this spot crucial.
Our Brandon Gdula has done a deep dive on single-game strategy. It's worth checking out before you make your lineups.