Rest differential is a term San Francisco 49ers fans are well aware of. Let’s begin with the term itself. Rest differential is the amount of rest each team has heading into their respective matchups. For example, if a team plays a Thursday night game heading into next week’s matchup on Sunday, they would have ten days between matchups. The 49ers have had no such luck the last two seasons. Not only did the 49ers have the third-worst rest differential, but the team also traveled the most miles of any NFL team.
So what about 2025 for the 49ers?