The Niners may be without two of their best pass-catching options at a critical moment.
"Adding insult to injury" might be a phrase describing the San Francisco 49ers' transition from Weeks 4 to 5.
Or, rather, "adding injury to insult."
Coming off a brutal 26-21 Week 4 loss to the Jacksonville Jaguars, head coach Kyle Shanahan's squad now has to put the ugly defeat in the rearview mirror as it prepares for a critical Thursday Night Football showdown on the road against the 3-1 Los Angeles Rams that'll determine the NFC West's leader.