The San Francisco 49ers finally have their schedule revealed for the 2025 season, and it seems to be one of the easiest in the NFL on paper.
However, not always do schedules be what they appear, as there are always trap games and tough opponents mixed in over an 18-week period. So, let’s rank the five toughest games on the 49ers schedule for 2025.
No. 5: Week 10 vs. Los Angeles Rams
At No. 5 is the second matchup between the 49ers and the Rams, which takes place at Levi’s Stadium in Week 10.