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Fansided · Sep 3, 2025

One big factor could make 49ers’ Week 1 matchup much less daunting

San Francisco 49ers tight end George Kittle (85) | Steph Chambers/GettyImagesSeattle used to be the most hostile atmosphere on the schedule for the 49ers, but that may have officially changed coming into their Week 1 encounter.

When it comes to the fixture every season, it goes without saying that it used to be the most hostile environment the San Francisco 49ers would face is the annual trip to Seattle.

Read More: Brock Purdy has chance to silence critics due to dire 49ers WR situation

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