The San Francisco 49ers knew they'd miss their five-time Pro Bowler Nick Bosa as they took on the Jacksonville Jaguars, but they might not have known how much. There was plenty of blame to go around for the Week 4 debacle that coincided with Brock Purdy's return to the starting lineup, but the impact of Bosa's absence stands tall among the issues as something that is not easily cleaned up.
Over the first couple of weeks, with a healthy Bosa, the Niners defense was instrumental in sealing wins. Case in point was Bosa himself, singlehandedly snatching victory in Week 1 with a critical strip sack of Sam Darnold, going on to recover the fumble and end the Seattle Seahawks' threat.