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As we saw in the Week 1 monsoon in Chicago, weather can be a great equalizer in football games. This week in Mexico City, the 49ers and Cardinals are going to play at more than 7,200 feet above sea level. That is a huge deal, and the team that uses the thin air to its advantage is going to win the game on Monday night.
First, the science of the whole operation. As altitude increases, the amount of gas molecules in the air decreases, reducing oxygen and pressure.