When the Seattle Seahawks traded Russell Wilson to the Denver Broncos a few years back, nobody was happier to see him leave the NFC West than the San Francisco 49ers.
During his decade-long run in the Pacific Northwest, Wilson absolutely tormented the Niners, going 16-4 against them in the regular season, while also leading Seattle to a 23-17 victory over San Francisco in the NFC Championship game following the 2013 campaign. The Seahawks, of course, then went on to win Super Bowl 48.
And even when he got to Denver in 2022, he led the Broncos to an 11-10 win over the 49ers in Week 3, upping his overall record against his longtime rivals to a ridiculous 18-4.