The San Francisco 49ers head into this weekend’s matchup against the Arizona Cardinals with a bit of an edge. The 49ers played last week on Thursday Night Football, while the Cardinals were on Monday Night Football. The 49ers get three extra days of rest, while the Cardinals get one less day of rest.
We don’t regularly see this kind of matchup, but over the past three years, there have been nine such instances. Over that span, the team that played on TNF is 5-4 straight up, and 7-2 against the spread.