Entering 2025, San Francisco 49ers second-year running back Isaac Guerendo might have been a name to watch among fantasy football fans.
After all, the Niners cleaned house during the offseason, executing a swarm of moves that depleted their offense, including trading their top rusher from 2024, Jordan Mason, to the Minnesota Vikings.
In theory, this bumped Guerendo up the depth chart to No. 2 behind All-Pro Christian McCaffrey, whose own injury concerns mandated fantasy owners have some sort of handcuff or contingency plan in place.
After all, the fourth-round draftee out of Louisville became a primary beneficiary amid McCaffrey's injuries in 2024 that limited him to just four games played, and Guerendo responded with a solid 420-yard, four-touchdown rookie year that saw him average 5 yards per carry.