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How will 49ers respond after 1st loss?

SANTA CLARA — It was not business as usual this week at 49ers headquarters.

On the most talkative 49ers team in years, the players didn’t seem eager to discuss their first loss of the season. The locker room was mostly empty Wednesday and Thursday. Players hung out in the mail room or the eating room or the bathroom while reporters stood and looked at their phones.

For the first time this season, the 49ers seemed apprehensive. The previous 10 weeks, the 49ers locker room was a nonstop party.

When they blew out the Carolina Panthers a few weeks ago, the 49ers were an undefeated juggernaut.