All-Pro running back Christian McCaffrey is dealing with a calf injury, which results in him being listed as questionable ahead of the San Francisco 49ers' regular-season opener.
If you're thinking this applies to the Niners' 2025 Week 1 NFC West showdown against the Seattle Seahawks, you'd be correct.
Also, if you're reminiscing about San Francisco's season opener against the New York Jets a year ago at this time, you'd be correct, too. And, in that particular showdown, McCaffrey ended up being inactive with what turned out to be achilles tendinitis stemming from calf issues, which ultimately led to him missing the first eight games of the year.