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Cardinals vs. 49ers: Betting odds, weather, injuries, matchups to watch

The San Francisco 49ers no longer have to worry about protecting their undefeated season after falling in heartbreaking overtime fashion to the Seattle Seahawks on Monday Night Football in Week 10.

Now at 8-1, the Niners instead shift their focus to their Week 11 opponent, the 3-6-1 Arizona Cardinals, who’ll look for some revenge after losing to San Francisco in prime time back in Week 9.

San Francisco still boasts the No. 2 overall scoring defense in the league. Yet the Cardinals managed to put a bit of a scare into this defense two weeks ago, staging a third- and fourth-quarter comeback, only to see the 49ers pull off the 28-25 win on Thursday Night Football.