The San Francisco 49ers currently are the best team in a very tough division of football, the NFC West. The Seattle Seahawks came to within a yard of winning the division last season, the Los Angeles Rams regressed but still had a winning record and were in the Wild Card race, and the Arizona Cardinals showed progression while pushing the Niners hard in both near-upset matchups.
The Seahawks will always remain a threat as long as Russell Wilson is their quarterback, but the Rams are much weaker after having to discard a lot of important players for cap reasons.