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Cardinals injury woes give 49ers huge opportunity to run up the score

The 2-0 San Francisco 49ers are poised to already do something in Week 3 that they failed to do last season: win two games within the NFC West.

Having already defeated the Seattle Seahawks in Week 1, a victory this Sunday over another division rival, the 2-0 Arizona Cardinals, would double head coach Kyle Shanahan's squad's NFC West win total from 2024's abysmal 6-11 campaign.

And the prospects for achieving this in the Niners' home opener are already lining up.

San Francisco has been no stranger to injury problems this season, highlighted by All-Pro tight end George Kittle (hamstring) landing on injured reserve after Week 1, while quarterback Brock Purdy (toe) missed Week 2's win over the New Orleans Saints, giving way to a solid outing by his backup, Mac Jones.