The San Francisco 49ers' injury woes this season have primarily hit the offense, and Week 3's NFC West bout against the Arizona Cardinals was already impacted with tight end George Kittle still on injured reserve, quarterback Brock Purdy still sidelined with a toe issue and wide receiver Jauan Jennings out with shoulder and ankle injuries.
Those absences were felt early, as Arizona's offense dominated the time of possession during the first quarter, leaving coordinator Robert Saleh's defense under siege for the bulk of the first half.
If that wasn't bad enough, watching All-Pro defensive end Nick Bosa leave the game late in the first quarter with what was reported as a knee injury only makes things worse.