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49ers will be without yet another one of their best weapons vs. Cardinals

The San Francisco 49ers' massive rash of injuries fortunately hasn't beset head coach Kyle Shanahan's squad too much early in in 2025.

At 2-0, the Niners have navigated losses to key players, including quarterback Brock Purdy (toe) and tight end George Kittle (hamstring), among others. And yet Shanahan and Co. have managed to pull off two road wins to begin the season.

Still, the injury bug hasn't exactly let up, and San Francisco will be without one of its best offensive weapons for its Week 3 home opener against its NFC West rivals, the 2-0 Arizona Cardinals.