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49ers vs. Cardinals: How to watch, stream, game time, and betting odds

It’s earlier than expected, but Trey Lance will make his debut today against the Arizona Cardinals (-5.5)

. He won’t have one of the 49ers’ best players in George Kittle. That puts pressure on other players to step it up. Looking at you, Brandon Aiyuk.

If today brings anything, it’ll bring excitement.

San Francisco 49ers (2-2) @ Arizona Cardinals (4-0)

Date: Sunday, October 10, 2021

Kickoff: 1:25 p.m. PT

Location: Glendale, Arizona

Network: Fox

Play-by-Play: Kevin Kugler

Color Analyst: Mark Sanchez

Sideline Reporter: Laura Okmin

Here’s a look at the TV map, courtesy of 506sports.