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49ers suffer most devastating injury possible in Week 1 opener vs. Seahawks

The San Francisco 49ers have a painful relationship with injuries, but the hope was an increasingly healthy squad would be at 100 percent on the eve of the regular season.

One player who didn't deal with any injuries during training camp or the preseason was tight end George Kittle, who was eyeing 2025 as an opportunity to continue his legendary climb up franchise leaderboards.

After notching the Niners' first touchdown of the season in Week 1's road bout versus the Seattle Seahawks, it seemed all was well on that front.

Unfortunately, that's about the only good news regarding Kittle from the contest.