The rain picked up just as the game kicked off. There was a pretty good drizzle, and the Cardinals went three-and-out to start the game. Not to be outdone, the 49ers punted after three plays themselves. Jimmy Garoppolo took a shot down the field to Jauan Jennings, but incidental contact was ruled, and the Niners brought out Mitch Wishnowsky.
Arizona found DeAndre Hopkins on the ensuing drive as he had three receptions for 40 yards, including a pair of first downs. The Niners held in the red zone and forced a Matt Prater 40-yard field goal but lost Charvarius Ward to a groin injury on the drive.