The San Francisco 49ers' 2025 campaign has already been defined by, yes, you guessed it: injuries. Despite a phenomenal 4-1 start to the season, San Francisco has once again been bitten by the injury bug, and it seems like no one is immune.
With George Kittle already on the short-term Injured Reserve and Nick Bosa out for the year, the 49ers were also without Brock Purdy, Jauan Jennings, Ricky Pearsall and a handful of other key depth players for their Week 5 matchup on Thursday Night Football against the Los Angeles Rams.
An early spot atop the NFC West division was on the line in primetime, and the 49ers were able to leave SoFi Stadium with a hard-earned win.