The San Francisco 49ers are such a perpetually injured team that they can't go one game without losing a key starter to some serious ailment. Even after a narrow win against the division rival Arizona Cardinals in Week 3, San Francisco received some awful news relating to pass-rusher Nick Bosa.
Bosa will miss the remainder of the 2025 season with a torn ACL, which now makes the second season in his pro career that was ended before October with an ACL injury. The 49ers will move ahead with Bryce Huff and rookie Mykel Williams as the starting edge rushers.