In 2012, the San Francisco 49ers selected former Illinois wide receiver A.J. Jenkins at the tail end of Round 1 of that year’s NFL Draft. He was targeted just once in his Niners career and was off the team a year later.
In the 1997 draft, San Francisco selected Virginia Tech quarterback Jim Druckenmiller at No. 26 overall. He appeared in only four games, starting one of them and had one touchdown against four interceptions before flaming out early the following year.
Both Jenkins and Druckenmiller were clear-cut busts in the NFL Draft.